Raif S Geha Selected Research

Filaggrin Proteins

1/2019	Injury, dysbiosis, and filaggrin deficiency drive skin inflammation through keratinocyte IL-1α release.
10/2018	MyD88 signaling in T regulatory cells by endogenous ligands dampens skin inflammation in filaggrin deficient mice.
6/2015	Filaggrin deficiency promotes the dissemination of cutaneously inoculated vaccinia virus.
2/2013	Filaggrin-dependent secretion of sphingomyelinase protects against staphylococcal α-toxin-induced keratinocyte death.
9/2009	Filaggrin-deficient mice exhibit TH17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Raif S Geha Research Topics

Disease

43	Inflammation (Inflammations) 02/2024 - 01/2002
31	Atopic Dermatitis (Atopic Eczema) 03/2024 - 09/2003
12	Infections 01/2023 - 08/2003
12	Wiskott-Aldrich Syndrome 10/2016 - 08/2002
9	Eosinophilia 01/2024 - 10/2003
8	Common Variable Immunodeficiency 12/2018 - 06/2007
7	Food Hypersensitivity (Food Allergy) 01/2019 - 06/2011
6	Colitis 11/2020 - 12/2008
6	Ectodermal Dysplasia (Aplasia Cutis Congenita) 01/2018 - 09/2004
6	Hypersensitivity (Allergy) 08/2015 - 01/2002
5	Virus Diseases (Viral Diseases) 01/2021 - 03/2013
5	Lymphopenia (Lymphocytopenia) 01/2020 - 08/2003
5	Primary Immunodeficiency Diseases 08/2014 - 08/2002
4	Hyperplasia 02/2024 - 01/2016
4	Eczema 01/2024 - 12/2015
4	Skin Diseases (Skin Disease) 10/2023 - 08/2004
4	Asthma (Bronchial Asthma) 01/2023 - 09/2003
4	COVID-19 01/2023 - 01/2020
4	Contact Dermatitis (Eczema, Contact) 01/2021 - 09/2010
4	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 01/2020 - 12/2008
4	Respiratory Hypersensitivity 01/2019 - 03/2002
4	Neoplasms (Cancer) 01/2019 - 08/2004
3	Anaphylaxis (Anaphylactic Shock) 10/2022 - 02/2013
3	Staphylococcal Infections 11/2021 - 10/2016
3	Bacterial Infections (Bacterial Infection) 10/2019 - 11/2010
3	Reinfection 11/2017 - 12/2014
3	Lymphoma (Lymphomas) 10/2017 - 09/2013
3	Job Syndrome (Hyper-IgE Syndrome) 11/2016 - 12/2008
3	Agammaglobulinemia (Hypogammaglobulinemia) 01/2016 - 08/2003
3	Kaposi Varicelliform Eruption (Eczema Herpeticum) 12/2015 - 12/2007
2	Cytopenia 01/2021 - 07/2019
2	Chronic Granulomatous Disease 11/2020 - 10/2017
2	Vasculitis (Vasculitides) 01/2020 - 01/2019
2	Autoimmune Hemolytic Anemia (Cold Agglutinin Disease) 07/2019 - 11/2017
2	Pruritus (Itching) 01/2019 - 01/2009
2	Dysbiosis 01/2019 - 11/2016
2	Diarrhea 11/2017 - 01/2016
2	Thrombocytopenia 1 11/2015 - 04/2011
2	Respiratory Tract Infections (Respiratory Tract Infection) 08/2015 - 08/2014
2	Dermatitis 02/2014 - 10/2003
2	Parasitic Diseases (Parasitic Disease) 12/2008 - 09/2003
2	DiGeorge Syndrome (Syndrome, DiGeorge) 12/2008 - 02/2006
2	Inborn Genetic Diseases (Disease, Hereditary) 10/2003 - 04/2002
1	Psoriasis (Pustulosis Palmaris et Plantaris) 10/2023
1	Superinfection 10/2023
1	Erythema elevatum diutinum 01/2023
1	Glomerulonephritis 01/2023

Drug/Important Bio-Agent (IBA)

27	AntigensIBA 02/2024 - 03/2002
17	Immunoglobulin E (IgE)IBA 01/2024 - 01/2002
14	CytokinesIBA 01/2023 - 03/2002
14	Proteins (Proteins, Gene)FDA Link 10/2017 - 08/2002
12	OvalbuminIBA 02/2024 - 01/2002
11	AllergensIBA 11/2020 - 01/2002
9	LigandsIBA 12/2018 - 06/2007
8	Interleukin-17 (Interleukin 17)IBA 01/2024 - 10/2007
7	Immunoglobulin G (IgG)IBA 08/2014 - 01/2002
6	Interleukin-4 (Interleukin 4)IBA 02/2024 - 10/2009
6	CalciumIBA 01/2016 - 10/2007
5	AutoantibodiesIBA 01/2023 - 11/2015
5	Intravenous Immunoglobulins (IVIG)FDA Link 01/2021 - 04/2003
5	Filaggrin ProteinsIBA 01/2019 - 09/2009
5	Cyclophilins (Cyclophilin)IBA 07/2011 - 10/2007
5	NF-kappa B (NF-kB)IBA 12/2008 - 10/2003
4	Interleukin-22 (IL-22)IBA 01/2024 - 01/2016
4	AntibodiesIBA 01/2023 - 09/2003
4	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 11/2020 - 12/2008
4	Messenger RNA (mRNA)IBA 01/2019 - 06/2006
4	Immunoglobulin M (IgM)IBA 10/2017 - 04/2004
3	Interleukin-4 Receptors (Interleukin 4 Receptor)IBA 10/2023 - 10/2003
3	HaptensIBA 09/2021 - 05/2009
3	Interleukin-13IBA 01/2021 - 10/2009
3	ChemokinesIBA 01/2020 - 07/2014
3	EnzymesIBA 01/2020 - 10/2012
3	T-Cell Antigen Receptors (T-Cell Receptor)IBA 01/2019 - 12/2005
3	Wiskott-Aldrich Syndrome ProteinIBA 01/2018 - 12/2003
3	Interleukin-33IBA 11/2017 - 01/2016
3	Immunoglobulin A (IgA)IBA 10/2017 - 04/2004
2	Phosphotransferases (Kinase)IBA 10/2023 - 03/2008
2	Adrenal Cortex Hormones (Corticosteroids)IBA 10/2023 - 12/2008
2	Anti-Bacterial Agents (Antibiotics)IBA 01/2022 - 01/2019
2	Interleukin-18 (Interleukin 18)IBA 01/2021 - 11/2017
2	Complement System Proteins (Complement)IBA 01/2021 - 10/2007
2	Dextran SulfateIBA 11/2020 - 07/2014
2	SaltsIBA 11/2020 - 07/2014
2	Nonsense Codon (Nonsense Mutation)IBA 11/2017 - 01/2015
2	MitogensIBA 10/2017 - 03/2016
2	VaccinesIBA 10/2017 - 10/2003
2	Thymic Stromal LymphopoietinIBA 01/2016 - 08/2008
2	InterferonsIBA 12/2015 - 06/2015
2	I-kappa B KinaseIBA 07/2010 - 10/2007
2	Interleukin-2 (IL2)IBA 12/2005 - 06/2002
1	Phosphodiesterase 4 InhibitorsIBA 03/2024
1	CeramidesIBA 10/2023
1	Janus Kinase InhibitorsIBA 10/2023
1	Ant VenomsIBA 10/2023
1	Interleukin-12 (IL 12)IBA 10/2023
1	Phosphates (Orthophosphate)IBA 10/2023

Therapy/Procedure

9	Therapeutics 10/2023 - 04/2003
4	Hematopoietic Stem Cell Transplantation 01/2020 - 12/2008
2	Cell Transplantation 07/2019 - 12/2010